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KMID : 0861020090240010059
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Korea Journal of Herbology
2009 Volume.24 No. 1 p.59 ~ p.71
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Effect of Mantidis and Mori Fructus On treatment of Osteoporosis In Ovariectomized Rats
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Lee Jae-Woo
Seo Bu-Il
Park Ji-Ha
Roh Seong-Soo
Kim Mi-Ryeo
Kim Yong-Hyun
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Abstract
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Objectives: The present study has been undertaken to investigate the effects of Mantidis and Mori Fructus on treatment of osteoporosis in ovariectomized rats.
Methods: In this experiment, the rats were ovariectomized. Rats were administered by Mantidis and Mori Fructus. The levels of bone mineral density, osteocalcin.ALP.calcium.phosphorus in serum, calcium. phosphorus.deoxypyridinoline in urine and calcium.phosphorus.ash weight in bone were measured.
Results: 1. The levels of femoral and fibula-tibial bone mineral density were significantly increased in comparison with OVX group at 4, 8 weeks in Mantidis group. And the levels of femoral and fibula-tibial bone mineral density were significantly increased in comparison with OVX group at 8 weeks in Mori Fructus group. 2. The levels of serum osteoclacin and ALP showed significant decrease in comparison with OVX group at 4, 8 weeks in Mantidis and Mori Fructus group. The levels of serum calcium showed significant decrease in comparison with OVX group at 4 weeks in Mantidis and Mori Fructus group. The levels of serum phosphorus showed significant decrease in comparison with OVX group at 4, 8 weeks in Mantidis and Mori Fructus group. 3. The levels of urine calcium, phosphorus and deoxypyridinoline showed significant decrease in comparison with OVX group in Mantidis and Mori Fructus group. 4. The levels of fibula-tibial calcium and phosphorus showed significant increase in comparison with OVX group in Mantidis group and Mori Fructus group. The levels of femoral calcium and phosphorus showed significant increase in comparison with OVX group in Mori Fructus group. The levels of femoral and fibula-tibial ash weight showed significant increase in comparison with OVX group in Mantidis group and Mori Fructus group.
Conclusions: Reviewing these experimetal results, it appeared that Mantidis and Mori Fructus had efficacy on treatment of osteoporosis.
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KEYWORD
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Mantidis, Mori Fructus, treatment of osteoporosis, ovariectomized rats
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